Development of dose-response calibration curve for dicentric chromosome induced by X-rays
نویسندگان
چکیده
منابع مشابه
Construction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
Premature Chromosome Condensation (PCC) appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to 60Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Anal...
متن کاملDose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50MeV proton beams
Background: The purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. Materials and Methods: Human peripheral blood lymphocytes were irradiated using proton beams (LET: 34.6 keV μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (CB) micronucleus (MN) assay. To determine th...
متن کاملdose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50mev proton beams
background: the purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. materials and methods: human peripheral blood lymphocytes were irradiated using proton beams (let: 34.6 kev μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (cb) micronucleus (mn) assay. to determine the efficie...
متن کاملconstruction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
premature chromosome condensation (pcc) appears to have a possible utility for biological dosimetry purposes. the pcc technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. for this purpose, human blood samples were exposed in vitro to 60co up to 10 gy and the pcc technique was performed immediately after irradiation. anal...
متن کاملCalibration Curve for Dicentric Chromosomes Induced in Human Blood Lymphocytes Exposed to Gamma Rays at a Dose Rate of 12.5 mGy/s
To develop a calibration curve for induction of dicentric chromosomes by radiation, we have used a 60Co gamma-ray source with dose rate of 12.5 mGy/s. Whole blood from 15 healthy donors was collected. Whole blood from each donor was divided equally into 8 parts for exposing to supposedly physical doses 0, 0.30, 0.50, 1.00, 1.50, 2.00, 3.00 and 4.00 Gy for a independent calibration curve. Whole ...
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ژورنال
عنوان ژورنال: Genome Integrity
سال: 2019
ISSN: 2041-9414
DOI: 10.4103/genint.genint_1_19